Threo-methylphenidate hydrochloride

Name: Threo -methylphenidate hydrochloride
Brand: Tocris Bioscience
SKU: 1812

Tocris Bioscience a Bio-Techne Brand

Catalog # 1812

Citations (3)

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Key Product Details

Description:	Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
Alternative Names:	Ritalin
Chemical Name:	Threo-methyl α-Phenyl-2-piperidineacetate hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	269.77

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Biological Activity for Threo-methylphenidate hydrochloride

Threo-methylphenidate hydrochloride is a psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Increases locomotor activity in vivo.

Technical Data for Threo-methylphenidate hydrochloride

M. Wt	269.77
Formula	C₁₄H₁₉NO₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	298-59-9
PubChem ID	45259401
InChi Key	JUMYIBMBTDDLNG-QNTKWALQSA-N
Smiles	[H][C@]1([C@H]([C@]2=CC=CC=C2)C(OC)=O)NCCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Threo-methylphenidate hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	13.49	50
	ethanol	26.98	100

Preparing Stock Solutions for Threo-methylphenidate hydrochloride

The following data is based on the product molecular weight 269.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.71 mL	18.53 mL	37.07 mL
5 mM	0.74 mL	3.71 mL	7.41 mL
10 mM	0.37 mL	1.85 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for Threo-methylphenidate hydrochloride

References are publications that support the biological activity of the product.

Askenasy Methylphenidate (Ritalin): behavioral studies in the rat. Int.J.Neurosci. 2007 PMID: 17454243
Leonard Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects. Human Psychopharm.

Citations for Threo-methylphenidate hydrochloride (3)

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Citations are publications that use Bio-Techne products. Selected citations for Threo-methylphenidate hydrochloride include:

Beerepoot et al. (2016) Pharmacological Chaperones of the DA Transporter Rescue DA Transporter Deficiency Syndrome Mutations in Heterologous Cells. J Biol Chem. 291:22053
PMID: 27555326
Poulin et al. (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol. 86:378
PMID: 25028482
Parker et al. (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. PLoS One. 231:2671
PMID: 24481568

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