(-)-Terreic acid

Name: (-)-Terreic acid
Brand: Tocris Bioscience
SKU: 1405

Tocris Bioscience a Bio-Techne Brand

Catalog # 1405

COA / SDS

Discontinued Product

1405 has been discontinued. View all Brutons Tyrosine Kinase (BTK) Inhibitors products.

Key Product Details

Description:	Selective inhibitor of BTK
Chemical Name:	(1R,6S)-3-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione
Purity:	≥99% (HPLC)
Molecular Weight:	154.12

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Biological Activity for (-)-Terreic acid

(-)-Terreic acid is a selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC₅₀ ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.

Technical Data for (-)-Terreic acid

M. Wt	154.12
Formula	C₇H₆O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	121-40-4
PubChem ID	91437
InChi Key	ATFNSNUJZOYXFC-RQJHMYQMSA-N
Smiles	CC1=C(O)C(=O)[C@@H]2O[C@@H]2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-Terreic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	3.08	20

Preparing Stock Solutions for (-)-Terreic acid

The following data is based on the product molecular weight 154.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	32.44 mL	162.21 mL	324.42 mL
1 mM	6.49 mL	32.44 mL	64.88 mL
2 mM	3.24 mL	16.22 mL	32.44 mL
10 mM	0.65 mL	3.24 mL	6.49 mL

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References for (-)-Terreic acid

References are publications that support the biological activity of the product.

Kawakami Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc.Natl.Acad.Sci.U.S.A. 1999 PMID: 10051623
Subramanian In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids. Toxicol.Lett. 1982 PMID: 7080093
Yamamoto Studies on terreic acid. Jpn.J.Antibiot. 1980 PMID: 7190624

Citations for (-)-Terreic acid

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