Terbinafine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6484
Selective K2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase
Discontinued Product
6484 has been discontinued.
View all Two-P Potassium Channels Activators products.
Key Product Details
Description
Selective K2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase
Product Description
Terbinafine hydrochloride is a selective TASK3 activator (pEC50 = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC50 = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.Product Specifications
Molecular Weight
327.89
Formula
C21H25N.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride
CAS Number
78628-80-5
PubChem ID
5282481
InChI Key
BWMISRWJRUSYEX-SZKNIZGXSA-N
SMILES
CN(CC1=CC=CC2=C1C=CC=C2)C/C=C/C#CC(C)(C)C.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.28 | 10 with gentle warming | |
| DMSO | 32.79 | 100 |
Preparing Stock Solutions
for Terbinafine hydrochloride
The following data is based on the product molecular weight 327.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.05 mL | 15.25 mL | 30.50 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.10 mL |
| 10 mM | 0.30 mL | 1.52 mL | 3.05 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wright Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3. Biochem.Biophys.Res.Commun. 2017 PMID: 28882594
- Petranyi Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 1984 PMID: 6547247
Product Specific Notices for Terbinafine hydrochloride
For research use only
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