Telmisartan

Name: Telmisartan
Brand: Tocris Bioscience
SKU: 5139

Tocris Bioscience, part of Bio-Techne | Catalog # 5139

Citations (2)

COA / SDS

AT1 antagonist; PPARγ partial agonist

Discontinued Product

5139 has been discontinued. View all Angiotensin AT1 Receptor Antagonists products.

Key Product Details

Description:	AT₁ antagonist; PPARγ partial agonist
Chemical Name:	4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid
Purity:	≥99% (HPLC)
Molecular Weight:	514.62

View Full Technical Details for Telmisartan

Technical Data
Citations

Biological Activity for Telmisartan

Telmisartan is an antagonist of the angiotensin II type 1 receptor (AT₁) (K_i = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.

Compound Libraries for Telmisartan

Telmisartan is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Telmisartan

M. Wt	514.62
Formula	C₃₃H₃₀N₄O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	144701-48-4
PubChem ID	65999
InChi Key	RMMXLENWKUUMAY-UHFFFAOYSA-N
Smiles	CCCC4=NC(C(C)=C3)=C(N4CC5=CC=C(C6=CC=CC=C6C(O)=O)C=C5)C=C3C2=NC1=CC=CC=C1N2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Telmisartan

References are publications that support the biological activity of the product.

Benson Identification of telmis. as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity. Hypertension 2004 PMID: 15007034
Ries 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J.Med.Chem. 1993 PMID: 8258826
Rong An adipose tissue-independent Ins-sensitizing action of telmisartan: a study in lipodystrophic mice. J.Pharmacol.Exp.Ther. 2009 PMID: 19770292