TCS 5861528

Name: TCS 5861528
Brand: Tocris Bioscience
SKU: 3938

Catalog # 3938 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

TRPA1 blocker

Key Product Details

Description:	TRPA1 blocker
Chemical Name:	2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	369.42

View Full Technical Details for TCS 5861528

Technical Data
Citations (1) / Reviews

Biological Activity for TCS 5861528

TCS 5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC₅₀ values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.

Compound Libraries for TCS 5861528

TCS 5861528 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TCS 5861528

M. Wt	369.42
Formula	C₁₉H₂₃N₅O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	332117-28-9
PubChem ID	2873523
InChi Key	ZUTUWJYMCADJHD-UHFFFAOYSA-N
Smiles	O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)CC)C=C3)=O)N(C)C(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS 5861528

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.94	100
	ethanol	3.69	10

Preparing Stock Solutions for TCS 5861528

The following data is based on the product molecular weight 369.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.53 mL	27.07 mL
5 mM	0.54 mL	2.71 mL	5.41 mL
10 mM	0.27 mL	1.35 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for TCS 5861528

References are publications that support the biological activity of the product.

Wei Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 2010 PMID: 20004676
Wei Spinal TRPA1 ion channels contribute to the cutaneous neurogenic inflammation in the rat. Neurosci.Letts. 2010 PMID: 20566388
Wei Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 2009 PMID: 19512877

Citations for TCS 5861528 (1)

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Citations are publications that use Bio-Techne products. Selected citations for TCS 5861528 include:

Ko et al. (2019) A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep. 9:2430
PMID: 30787340

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