TCS 2312

Name: TCS 2312
Brand: Tocris Bioscience
SKU: 3038

Tocris Bioscience, part of Bio-Techne | Catalog # 3038

Citations (8)

COA / SDS

Potent Chk1 inhibitor

Discontinued Product

3038 has been discontinued. View all Checkpoint Kinase Inhibitors products.

Key Product Details

Description:	Potent Chk1 inhibitor
Chemical Name:	4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol
Purity:	≥97% (HPLC)
Molecular Weight:	412.48

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Technical Data
Citations

Biological Activity for TCS 2312

TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor (K_i = 0.38 nM, EC₅₀ = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.

Technical Data for TCS 2312

M. Wt	412.48
Formula	C₂₅H₂₄N₄O₂
Storage	Store at -80°C
Purity	≥97% (HPLC)
CAS Number	838823-31-7
PubChem ID	11258443
InChi Key	BYFCMDWKTJJQGR-UHFFFAOYSA-N
Smiles	OC1=CC(O)=CC=C1C2=CC=C(C3=CC(NC4=CC=C(CNC5CC5)C=C4)=NN3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TCS 2312

References are publications that support the biological activity of the product.

Teng Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J.Med.Chem. 2007 PMID: 17887663

TCS 2312

Tocris Bioscience, part of Bio-Techne | Catalog # 3038

Key Product Details

Biological Activity for TCS 2312

Technical Data for TCS 2312

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TCS 2312

Product Documents for TCS 2312

COA

Certificate of Analysis

SDS

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