TCS 1205

Name: TCS 1205
Brand: Tocris Bioscience
SKU: 3941

Tocris Bioscience, part of Bio-Techne | Catalog # 3941

COA / SDS

GABAA agonist; displays subtype selectivity

Discontinued Product

3941 has been discontinued. View all GABA-A Receptor Agonists products.

Key Product Details

Description:	GABA_A agonist; displays subtype selectivity
Chemical Name:	5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
Purity:	≥99% (HPLC)
Molecular Weight:	337.33

View Full Technical Details for TCS 1205

Technical Data
Citations

Biological Activity for TCS 1205

GABA_A α2 agonist and GABA_A α1 partial agonist in vitro (K_i values are 14 and 121 nM respectively). Exhibits non-sedative anxiolytic activity in vivo.

Technical Data for TCS 1205

M. Wt	337.33
Formula	C₁₈H₁₅N₃O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	355022-97-8
PubChem ID	10315001
InChi Key	VCKKJKQZHHPPDR-LLVKDONJSA-N
Smiles	O=C(C(N[C@H](C)C3=CC=CC=C3)=O)C2=CNC1=CC=C([N+]([O-])=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TCS 1205

References are publications that support the biological activity of the product.

Taliani Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABA_A) κ₂ benzodiazepine receptor. J.Med.Chem. 2009 PMID: 19469479
Primofiore Novel N-(arylalkyl)indol-3-ylglyoxylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. J.Med.Chem. 2001 PMID: 11428922

TCS 1205

Tocris Bioscience, part of Bio-Techne | Catalog # 3941

Key Product Details

Biological Activity for TCS 1205

Technical Data for TCS 1205

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TCS 1205

Product Documents for TCS 1205

COA

Certificate of Analysis

SDS

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