TC-N 22A
Tocris Bioscience, part of Bio-Techne | Catalog # 4370
Potent and selective positive allosteric modulator of mGlu4 receptors
Discontinued Product
4370 has been discontinued.
View all Group III mGluR Modulators products.
Key Product Details
Description
Potent and selective positive allosteric modulator of mGlu4 receptors
Product Description
TC-N 22A is a potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4 over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 values are > 10 μM). Brain penetrant.Product Specifications
Molecular Weight
283.35
Formula
C14H13N5S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4,5,6,8-Tetrahydro-N-2-pyridinylpyrazolocyclohepta[1,2]thiazol-2-amine
CAS Number
1314140-00-5
PubChem ID
46836562
InChI Key
DBISXWCOHGUFSF-UHFFFAOYSA-N
SMILES
C2(SC(NC4=NC=CC=C4)=N3)=C3C1=CNN=C1CCC2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.17 | 50 |
Preparing Stock Solutions
for TC-N 22A
The following data is based on the product molecular weight 283.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.06 mL | 35.29 mL | 70.58 mL |
| 2.5 mM | 1.41 mL | 7.06 mL | 14.12 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
| 25 mM | 0.14 mL | 0.71 mL | 1.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hong Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J.Med.Chem. 2011 PMID: 21688779
Product Specific Notices for TC-N 22A
For research use only
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