TAT-cyclo-CLLFVY

Name: TAT-cyclo-CLLFVY
Brand: Tocris Bioscience
SKU: 5582

Tocris Bioscience, part of Bio-Techne | Catalog # 5582

Citations (7)

COA / SDS

Selective HIF-1 dimerization inhibitor

Discontinued Product

5582 has been discontinued. View all HIF Inhibitors products.

Key Product Details

Description:	Selective HIF-1 dimerization inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	2559.1

View Full Technical Details for TAT-cyclo-CLLFVY

Technical Data
Citations

Biological Activity for TAT-cyclo-CLLFVY

TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC₅₀ = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

Technical Data for TAT-cyclo-CLLFVY

M. Wt	2559.1
Formula	C₁₁₁H₁₈₈N₄₂O₂₄S₂
Single Letter Sequence	CLLFVY CGRKKRRQRRRPPQ* (Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1446322-66-2
PubChem ID	72192490
InChi Key	AWUUHEHYNQGEFC-XLZVTALKSA-N
Smiles	[H]N[C@@H](CSSC[C@@H]1N([H])C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TAT-cyclo-CLLFVY

References are publications that support the biological activity of the product.

Miranda A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J.Am.Chem.Soc. 2013 PMID: 23796364

TAT-cyclo-CLLFVY

Tocris Bioscience, part of Bio-Techne | Catalog # 5582

Key Product Details

Biological Activity for TAT-cyclo-CLLFVY

Technical Data for TAT-cyclo-CLLFVY

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TAT-cyclo-CLLFVY

Product Documents for TAT-cyclo-CLLFVY

COA

Certificate of Analysis

SDS

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