Targapremir 210
Tocris Bioscience, part of Bio-Techne | Catalog # 6586
Inhibits formation of miR-210
Discontinued Product
6586 has been discontinued.
View all DNA, RNA and Protein Synthesis Inhibitors products.
Key Product Details
Description
Inhibits formation of miR-210
Product Description
Targapremir 210 inhibits formation of mature miR-210 (IC50 = 200 nM) by binding to Dicer binding site of the miR-210 hairpin precursor (Kd = 200 nM) and inhibits Dicer processing of the miRNA. Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.Product Specifications
Molecular Weight
592.71
Formula
C32H36N10O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(3-Azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]butanamide
CAS Number
1049722-30-6
PubChem ID
44221088
InChI Key
PAYVJEWMAWLKAP-UHFFFAOYSA-N
SMILES
CN1CCN(C2=CC=C3N=C(C4=CC=C5N=C(C6=CC(OCCCC(NCCCN=[N+]=[N-])=O)=CC=C6)NC5=C4)NC3=C2)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.27 | 100 | |
| Ethanol | 59.27 | 100 |
Preparing Stock Solutions
for Targapremir 210
The following data is based on the product molecular weight 592.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.69 mL | 8.44 mL | 16.87 mL |
| 5 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 10 mM | 0.17 mL | 0.84 mL | 1.69 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Childs-Disney Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS.Chem.Biol 2012 PMID: 22332923
- Costales Small molecule inhibition of microRNA-210 reprograms an oncogenic hypoxic circuit. J.Am.Chem.Soc. 2017 PMID: 28240549
Product Specific Notices for Targapremir 210
For research use only
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