Talsupram hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4352
Selective inhibitor of noradrenalin transporters
Discontinued Product
4352 has been discontinued.
View all Adrenergic Transporter Inhibitors products.
Key Product Details
Description
Selective inhibitor of noradrenalin transporters
Product Description
Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor; exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Antidepressant.Product Specifications
Molecular Weight
347.95
Formula
C20H25NS.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1,3-Dihydro-N,3,3-trimethyl-1-phenylbenzo[c]thiophene-1-propanamine hydrochloride
CAS Number
25487-28-9
PubChem ID
33013
InChI Key
YMZCMCDSCRSIBS-UHFFFAOYSA-N
SMILES
CC2(C)SC(C3=CC=CC=C3)(CCCNC)C1=CC=CC=C12.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 6.96 | 20 | |
| DMSO | 34.8 | 100 |
Preparing Stock Solutions
for Talsupram hydrochloride
The following data is based on the product molecular weight 347.95
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.37 mL | 28.74 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.75 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schou Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol.
- Rowlett Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J.Pharmacol.Exp.Ther. 2004 PMID: 14985417
- McConathy Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the NE transporter. Nucl.Med.Biol. 2004 PMID: 15246361
Product Specific Notices for Talsupram hydrochloride
For research use only
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