TACA

Catalog # 0181

Citations (1)

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Key Product Details

Description:	GABA_A agonist; also GABA-T substrate and GABA uptake inhibitor
Chemical Name:	trans-4-Aminocrotonic acid
Molecular Weight:	101.1

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Biological Activity

The trans-isomer of CACA. Potent GABA_A agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABA_A-ρ agonist.

Technical Data

M. Wt	101.1
Formula	C₄H₇NO₂
Storage	Store at RT
CAS Number	38090-53-8
PubChem ID	5310987
InChi Key	FMKJUUQOYOHLTF-OWOJBTEDSA-N
Smiles	NC/C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 101.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	9.89 mL	49.46 mL	98.91 mL
5 mM	1.98 mL	9.89 mL	19.78 mL
10 mM	0.99 mL	4.95 mL	9.89 mL
50 mM	0.20 mL	0.99 mL	1.98 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Chebib Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABA_C receptor antagonists. Br.J.Pharmacol. 1997 PMID: 9422798
Johnston cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 1975 PMID: 234147
Johnston GABA_C receptors: relatively simple transmitter-gated ion channels. TiPS 1996 PMID: 8885697

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for TACA include:

Jensen (2013) Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa. PLoS One. 8:e79126
PMID: 24205371

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Product Datasheets

COA

Certificate of Analysis

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TACA

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Biological Activity

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Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

SDS

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