TACA

Catalog # 0181

Citations (1)

COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	GABA_A agonist; also GABA-T substrate and GABA uptake inhibitor
Chemical Name:	trans-4-Aminocrotonic acid
Molecular Weight:	101.1

View Full Technical Details for TACA

Complete Your Research

Biological Activity

The trans-isomer of CACA. Potent GABA_A agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABA_A-ρ agonist.

Technical Data

M. Wt	101.1
Formula	C₄H₇NO₂
Storage	Store at RT
CAS Number	38090-53-8
PubChem ID	5310987
InChi Key	FMKJUUQOYOHLTF-OWOJBTEDSA-N
Smiles	NC/C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 101.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	9.89 mL	49.46 mL	98.91 mL
5 mM	1.98 mL	9.89 mL	19.78 mL
10 mM	0.99 mL	4.95 mL	9.89 mL
50 mM	0.20 mL	0.99 mL	1.98 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Chebib Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABA_C receptor antagonists. Br.J.Pharmacol. 1997 PMID: 9422798
Johnston GABA_C receptors: relatively simple transmitter-gated ion channels. TiPS 1996 PMID: 8885697
Johnston cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 1975 PMID: 234147

Citations for TACA (1)

Showing 1 - 1 of 1 citation Showing All

View all citations for the Small Molecules and Peptides platform.

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for TACA include:

Jensen (2013) Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa. PLoS One. 8:e79126
PMID: 24205371

There are no citations that match your criteria.