T2AA
Tocris Bioscience, part of Bio-Techne | Catalog # 4723
PCNA inhibitor
Discontinued Product
4723 has been discontinued.
View all DNA, RNA and Protein Synthesis Inhibitors products.
Product Description
T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.Licensing Information
Sold under license from St. Jude Childrens Research HospitalProduct Specifications
Molecular Weight
511.09
Formula
C15H15I2NO3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
CAS Number
1380782-27-3
PubChem ID
71185540
InChI Key
NKOSKXJRVWVXRI-JTQLQIEISA-N
SMILES
IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.11 | 100 |
Preparing Stock Solutions
for T2AA
The following data is based on the product molecular weight 511.09
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.96 mL | 9.78 mL | 19.57 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.91 mL |
| 10 mM | 0.20 mL | 0.98 mL | 1.96 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Punchihewa Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 2012 PMID: 22383522
Product Specific Notices for T2AA
For research use only
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