T2AA

Name: T2AA
Brand: Tocris Bioscience
SKU: 4723
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4723

(1)

Citations (6)

COA / SDS

PCNA inhibitor

Discontinued Product

4723 has been discontinued. View all DNA, RNA and Protein Synthesis Inhibitors products.

Key Product Details

Description:	PCNA inhibitor
Chemical Name:	(βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
Purity:	≥98% (HPLC)
Molecular Weight:	511.09

View Full Technical Details for T2AA

Technical Data
Citations / Reviews (1)

Biological Activity for T2AA

T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC₅₀ ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.

Licensing Information

Sold under license from St. Jude Childrens Research Hospital

Technical Data for T2AA

M. Wt	511.09
Formula	C₁₅H₁₅I₂NO₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1380782-27-3
PubChem ID	71185540
InChi Key	NKOSKXJRVWVXRI-JTQLQIEISA-N
Smiles	IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for T2AA

References are publications that support the biological activity of the product.

Punchihewa Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 2012 PMID: 22383522