T16Ainh - A01

Tocris Bioscience, part of Bio-Techne | Catalog # 4538

Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor
Discontinued Product
4538 has been discontinued. View all Calcium-activated Chloride Channel Blockers products.

Key Product Details

Description

Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor

View all Calcium-activated Chloride Channel Blockers »

Product Description

T16Ainh - A01 is an inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro.

Product Specifications

Molecular Weight

416.52

Formula

C19H20N4O3S2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide

CAS Number

552309-42-9

PubChem ID

3193184

InChI Key

QSIYTNYMBWYHAA-UHFFFAOYSA-N

SMILES

CC1=NC(SCC(NC2=NC(C3=CC=C(OC)C=C3)=CS2)=O)=NC(O)=C1CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.65 100

Preparing Stock Solutions for T16Ainh - A01

The following data is based on the product molecular weight 416.52

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.40 mL 12.00 mL 24.01 mL
5 mM 0.48 mL 2.40 mL 4.80 mL
10 mM 0.24 mL 1.20 mL 2.40 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for T16Ainh - A01

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for T16Ainh - A01

For research use only

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