Key Product Details
Description: | Selective CB1 inverse agonist |
Alternative Names: | Rimonabant hydrochloride |
Chemical Name: | N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 500.25 |
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Citations for SR 141716A (18)
Citations are publications that use Bio-Techne products. Selected citations for SR 141716A include:
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Pedersen et al.
(2021)
A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors
J Biol Chem.
296:100503
PMID: 33684444 -
Jimenez-Blasco et al.
(2020)
Glucose metabolism links astroglial mitochondria to cannabinoid effects.
Nature.
583:603
PMID: 32641832 -
Cecconi et al.
(2019)
Role of Major Endocannabinoid-Binding Receptors during Mouse Oocyte Maturation.
Int J Mol Sci.
20
PMID: 31212770 -
Khan et al.
(2018)
Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma.
BMC Cancer.
18:583
PMID: 29792186 -
Jiang et al.
(2017)
Antidepressant-like effects of fenofi. in mice via the hippocampal brain-derived neurotrophic factor signalling pathway.
Br J Pharmacol.
174:177
PMID: 27861729 -
Klingerman et al.
(2016)
Acute Metabolic Effects of olanz. Depend on Dose and Injection Site.
Dose Response.
13:1559325815618910
PMID: 26740814 -
Hayase
(2016)
Putative Epigenetic Involvement of the Endocannabinoid System in Anxiety- and Depression-Related Behaviors Caused by Nicotine as a Stressor.
PLoS One.
11:e0158950
PMID: 27404492 -
Bruijnzeel et al.
(2016)
Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats.
PLoS One.
11:e0153327
PMID: 27065006 -
Tang and Alger
(2015)
Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.
J Neurosci.
35:3938
PMID: 25740522 -
Mahmoud et al.
(2015)
(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs.
Mol Pharmacol.
87:197
PMID: 25411367 -
Marcu et al.
(2013)
Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.
J Pharmacol Exp Ther.
345:189
PMID: 23426954 -
Sumislawski et al.
(2011)
Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation.
Neuropsychopharmacology.
36:2750
PMID: 21849983 -
Kapur et al.
(2008)
Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction.
J Pharmacol Exp Ther.
325:341
PMID: 18174385 -
Graham et al.
(2006)
Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway.
Br J Pharmacol.
281:29085
PMID: 16864584 -
Kettunen et al.
(2005)
Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network.
Neuron.
45:95
PMID: 15629705 -
Stanford et al.
(2001)
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
Br J Pharmacol.
133:825
PMID: 11454655 -
Martin et al.
(2000)
Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human.
Front Mol Neurosci.
129:1707
PMID: 10780977 -
MacLennan et al.
(1998)
Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors.
Br J Pharmacol.
124:619
PMID: 9690851
There are no citations that match your criteria.
Customer Reviews for SR 141716A (1)
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Species: MouseAssay Type: Ex VivoCell Line/Tissue: Bed nucleus of the stria terminalisSR 141716A was solubilized in DMSO and bath applied at a 5 micromolar concentration. It effectively blocked CB1-receptor-dependent long term depression of evoked excitatory postsynaptic current in the bed nucleus of the stria terminalis.
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