SR 141716A

Name: SR 141716A
Brand: Tocris Bioscience
SKU: 0923
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0923

(2)

Citations (126)

COA / SDS

Selective CB1 inverse agonist

Key Product Details

Description:	Selective CB₁ inverse agonist
Alternative Names:	Rimonabant hydrochloride
Chemical Name:	N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	500.25

View Full Technical Details for SR 141716A

Technical Data
Citations / Reviews (2)

Biological Activity for SR 141716A

SR 141716A is a potent and selective cannabinoid CB₁ receptor antagonist (K_i= 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (Cat.No. 1038) (IC₅₀ = 48 nM). Displays no activity at CB₂ receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats. Also μ-opioid receptor antagonist (K_i = 652 nm)

Technical Data for SR 141716A

M. Wt	500.25
Formula	C₂₂H₂₁Cl₃N₄O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	158681-13-1
PubChem ID	104849
InChi Key	REOYOKXLUFHOBV-UHFFFAOYSA-N
Smiles	O=C(NN4CCCCC4)C1=NN(C3=CC=C(Cl)C=C3Cl)C(C2=CC=C(Cl)C=C2)=C1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 141716A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.02	100

Preparing Stock Solutions for SR 141716A

The following data is based on the product molecular weight 500.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	10.00 mL	19.99 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for SR 141716A

References are publications that support the biological activity of the product.

Seely AM-251 and rimon. act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies. Neuropharmacology 2012 PMID: 22771770
Colombo Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. Life Sci. 1998 PMID: 9718088
Rinaldi-Carmona SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 1994 PMID: 8070571
Rinaldi-Carmona Biochemical and pharmacological characterisation of SR 141716A, the first potent and selective brain cannabinoid receptor antagonist. Life Sci. 1995 PMID: 7776817
Janiak Blockade of cannabinoid CB₁ receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats. Kidney Int. 2007 PMID: 17882151