SKA 121

Tocris Bioscience, part of Bio-Techne | Catalog # 6398

Positive allosteric modulator of KCa3.1 (IK) channels
Discontinued Product
6398 has been discontinued. View all Ca2+-Activated Potassium Channel Activators products.

Key Product Details

Description

Positive allosteric modulator of KCa3.1 (IK) channels

View all Ca2+-Activated Potassium Channel Activators »

Product Description

SKA 121 is a positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50 = 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KV and NaV channels. Potentiates bradykinin-induced vasodilation ex vivo. Lowers mean arterial blood pressure in normotensive and hypertensive mice.

Product Specifications

Molecular Weight

198.23

Formula

C12H10N2O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-Methylnaphth[2,1-d]oxazol-2-amine

CAS Number

1820708-73-3

PubChem ID

91827362

InChI Key

JEGUERWMMMQFJV-UHFFFAOYSA-N

SMILES

NC(O1)=NC2=C1C3=CC=CC=C3C(C)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.82 100
Ethanol 9.91 50

Preparing Stock Solutions for SKA 121

The following data is based on the product molecular weight 198.23

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.04 mL 25.22 mL 50.45 mL
5 mM 1.01 mL 5.04 mL 10.09 mL
10 mM 0.50 mL 2.52 mL 5.04 mL
50 mM 0.10 mL 0.50 mL 1.01 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SKA 121

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SKA 121

For research use only

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