SF 1670 is a PTPN2 and PTEN inhibitor (IC₅₀values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP₃ signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.

Product Specifications

Molecular Weight

307.34

Formula

C₁₉H₁₇NO₃

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide

CAS Number

345630-40-2

PubChem ID

9926586

InChI Key

VZQDDSYKVYARDW-UHFFFAOYSA-N

SMILES

O=C2C1=CC=CC=C1C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.73	100

Preparing Stock Solutions for SF 1670

The following data is based on the product molecular weight 307.34

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.27 mL	32.54 mL
5 mM	0.65 mL	3.25 mL	6.51 mL
10 mM	0.33 mL	1.63 mL	3.25 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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Background References

References are publications that support the biological activity of the product.

Le Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor. BMB Rep. 2017 PMID: 28228214
Li Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 2011 PMID: 21521784

SF 1670

Tocris Bioscience, part of Bio-Techne | Catalog # 5020

Key Product Details

Description

Alternative Names

View all Protein Tyrosine Phosphatase Inhibitors »

Product Description