Selexipag

Name: Selexipag
Brand: Tocris Bioscience
SKU: 3351

Tocris Bioscience, part of Bio-Techne | Catalog # 3351

COA / SDS

Selective prostacyclin IP1 receptor agonist

Discontinued Product

3351 has been discontinued. View all Prostanoid Receptor Agonists products.

Key Product Details

Description:	Selective prostacyclin IP₁ receptor agonist
Alternative Names:	NS-304,ACT-293987
Chemical Name:	2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	496.62

View Full Technical Details for Selexipag

Technical Data
Citations

Biological Activity for Selexipag

Selexipag is a selective prostacyclin IP₁ receptor agonist (K_i values are 260 and 2100 nM and for human and rat IP receptors, and >10 μM for EP_1-4, DP, FP, and TP receptors). Prodrug for the active form of MRE 269. Ameliorates vascular endothelial dysfunction and increases femoral skin blood flow in rats. Orally available.

Licensing Information

Sold with the permission of Nippon Shinyaku Co.

Compound Libraries for Selexipag

Selexipag is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Selexipag

M. Wt	496.62
Formula	C₂₆H₃₂N₄O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	475086-01-2
PubChem ID	9913767
InChi Key	QXWZQTURMXZVHJ-UHFFFAOYSA-N
Smiles	CC(C)N(CCCCOCC(NS(C)(=O)=O)=O)C1=NC(C3=CC=CC=C3)=C(C2=CC=CC=C2)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Selexipag

References are publications that support the biological activity of the product.

Kuwano A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active fo J.Pharmacol.Exp.Ther. 2008 PMID: 18552131
Morrison Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function. J.Pharmacol.Exp.Ther. 2010 PMID: 20660124
Kuwano 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. J.Pharmacol.Exp.Ther. 2007 PMID: 17545310