SCH 529074
Tocris Bioscience, part of Bio-Techne | Catalog # 4240
Restores mutant p53 activity
Discontinued Product
4240 has been discontinued.
View all Additional p53-related Compounds products.
Key Product Details
Description
Restores mutant p53 activity
Product Description
SCH 529074 is a restores mutant p53 activity. Binds p53 DNA binding domain (Kd = 1-2 μM) and restores wild-type function to many oncogenic mutants by acting as a chaperone. Inhibits ubiquitination of p53 by HDM2. Triggers apoptosis in tumor cell lines and reduces tumor growth in a xenograft model.Product Specifications
Molecular Weight
563.56
Formula
C31H36Cl2N6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine
CAS Number
922150-11-6
PubChem ID
12001922
InChI Key
NCAJLQDPTZBGJV-UHFFFAOYSA-N
SMILES
CN(C)CCCNC2=NC(CN3CCN(C(C5=CC=C(Cl)C=C5)C4=CC=C(Cl)C=C4)CC3)=NC1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10 with sonication | ||
| Ethanol | 100 |
Preparing Stock Solutions
for SCH 529074
The following data is based on the product molecular weight 563.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.77 mL | 8.87 mL | 17.74 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.55 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.77 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Essmann & Schulze-Osthoff Translational approaches targeting the p53 pathway for anti-cancer therapy. Br.J.Pharmacol. 2012 PMID: 21718309
- Demma SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. J.Biol.Chem. 2010 PMID: 20124408
Product Specific Notices for SCH 529074
For research use only
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