SC 58125

Name: SC 58125
Brand: Tocris Bioscience
SKU: 2895

Tocris Bioscience a Bio-Techne Brand

Catalog # 2895

Citations (1)

COA / SDS

Discontinued Product

2895 has been discontinued. View all Cyclooxygenase Inhibitors products.

Key Product Details

Description:	Selective cyclooxygenase-2 (COX-2) inhibitor
Chemical Name:	5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
Purity:	≥98% (HPLC)
Molecular Weight:	384.35

View Full Technical Details for SC 58125

Biological Activity for SC 58125

SC 58125 is a selective cyclooxygenase 2 (COX-2) inhibitor (IC₅₀ values are 0.04 and >100 μM for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for SC 58125

M. Wt	384.35
Formula	C₁₇H₁₂F₄N₂O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	162054-19-5
PubChem ID	115239
InChi Key	JHBIMJKLBUMNAU-UHFFFAOYSA-N
Smiles	FC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(C)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SC 58125

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.44	100
	ethanol	9.61	25

Preparing Stock Solutions for SC 58125

The following data is based on the product molecular weight 384.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.60 mL	13.01 mL	26.02 mL
5 mM	0.52 mL	2.60 mL	5.20 mL
10 mM	0.26 mL	1.30 mL	2.60 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SC 58125

References are publications that support the biological activity of the product.

Williams A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established colon cancer xenografts. Neoplasia 2001 PMID: 11687954
Gierse A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 1996 PMID: 8663121
Seibert Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc.Natl.Acad.Sci.USA

Citations for SC 58125 (1)

Showing 1 - 1 of 1 citation Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for SC 58125 include:

Lee et al. (2018) CCL17 blockade as a therapy for osteoarthritis pain and disease. Arthritis Res Ther. 20:62
PMID: 29622035

There are no citations that match your criteria.