SC 514

Tocris Bioscience, part of Bio-Techne | Catalog # 3318

IKKβ inhibitor; attenuates NF-κB-induced gene expression
Discontinued Product
3318 has been discontinued. View all IkB Kinase Inhibitors products.

Key Product Details

Description

IKKβ inhibitor; attenuates NF-κB-induced gene expression

View all IkB Kinase Inhibitors »

Product Description

SC 514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Attenuates NF-κB-induced gene expression of IL-6, IL-8 and COX-2 in synovial fibroblasts (IC50 values are 20, 20 and 8 μM respectively). Reduces iNOS induction and exhibits anti-inflammatory activity in vivo.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Product Specifications

Molecular Weight

224.30

Formula

C9H8N2OS2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-Amino-[2',3'-bithiophene]-5-carboxamide

CAS Number

354812-17-2

PubChem ID

2807869

InChI Key

BMUACLADCKCNKZ-UHFFFAOYSA-N

SMILES

NC1=C(C(N)=O)SC(C2=CSC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.43 100
Ethanol 2.24 10

Preparing Stock Solutions for SC 514

The following data is based on the product molecular weight 224.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.46 mL 22.29 mL 44.58 mL
5 mM 0.89 mL 4.46 mL 8.92 mL
10 mM 0.45 mL 2.23 mL 4.46 mL
50 mM 0.09 mL 0.45 mL 0.89 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for SC 514

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SC 514

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.