SB 268262
Tocris Bioscience, part of Bio-Techne | Catalog # 4314
Selective non-peptide CGRP antagonist
Discontinued Product
4314 has been discontinued.
View all Calcitonin and Related Receptor Antagonists products.
Key Product Details
Description
Selective non-peptide CGRP antagonist
Product Description
SB 268262 is a selective non-peptide CGRP1 antagonist. Inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively).Licensing Information
Sold with the permission of GlaxoSmithKline.Product Specifications
Molecular Weight
401.46
Formula
C18H15N3O4S2
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
CAS Number
217438-17-0
PubChem ID
6918567
InChI Key
YXHLPJQQPOMPGE-UHFFFAOYSA-N
SMILES
O=S(C2=NC=CS2)C1=CC=C(C(N(C)C3=CC=CC=C3C)=O)C=C1[N+]([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.07 | 50 |
Preparing Stock Solutions
for SB 268262
The following data is based on the product molecular weight 401.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.98 mL | 24.91 mL | 49.82 mL |
| 2.5 mM | 1.00 mL | 4.98 mL | 9.96 mL |
| 5 mM | 0.50 mL | 2.49 mL | 4.98 mL |
| 25 mM | 0.10 mL | 0.50 mL | 1.00 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Aiyar Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J.Pharmacol.Exp.Ther. 2001 PMID: 11181905
Product Specific Notices for SB 268262
For research use only
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