SB 205384

Name: SB 205384
Brand: Tocris Bioscience
SKU: 1512

Tocris Bioscience a Bio-Techne Brand

Catalog # 1512

Citations (2)

COA / SDS

Discontinued Product

1512 has been discontinued. View all GABA-A Receptor Modulators products.

Key Product Details

Description:	GABA_A modulator; slows current decay
Chemical Name:	4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	330.4

View Full Technical Details for SB 205384

Biological Activity for SB 205384

SB 205384 is a GABA_A receptor modulator; slows current decay. Potentiates α6, α3 and α5-subunit-containing receptors (EC₅₀ values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits.

Technical Data for SB 205384

M. Wt	330.4
Formula	C₁₇H₁₈N₂O₃S
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	160296-13-9
PubChem ID	197690
InChi Key	JDTZAGLGBRRCJT-UHFFFAOYSA-N
Smiles	CC#CCOC(=O)C1=C(C)N=C2SC3=C(CCC(O)C3)C2=C1N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 205384

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.52	50
	1eq. HCl	33.04	100

Preparing Stock Solutions for SB 205384

The following data is based on the product molecular weight 330.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.13 mL	30.27 mL
5 mM	0.61 mL	3.03 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for SB 205384

References are publications that support the biological activity of the product.

Heidelberg SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with J.Pharmacol.Exp.Ther. 2013 PMID: 23902941

Hutcheon Developmental change in GABA_A receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J.Physiol. 2000 PMID: 10618148
Meadows SB-205384: a GABA_A receptor modulator with novel mechanism of action that shows subunit selectivity. Br.J.Pharmacol. 1998 PMID: 9559912
Meadows Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br.J.Pharmacol. 1997 PMID: 9257911

Citations for SB 205384 (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SB 205384 include:

Heidelberg et al. (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits. J Pharmacol Exp Ther. 347:235
PMID: 23902941
Miller et al. (2010) Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice. Sci Rep. 21:247
PMID: 20512339

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