Sarafotoxin S6c

Name: Sarafotoxin S6c
Brand: Tocris Bioscience
SKU: 1175

Tocris Bioscience, part of Bio-Techne | Catalog # 1175

Citations (8)

COA / SDS

Selective ETB agonist

Discontinued Product

1175 has been discontinued. View all Endothelin ETB Receptor Agonists products.

Technical Data
Citations

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective ETB agonist

View all Endothelin ETB Receptor Agonists »

Product Description

Sarafotoxin S6c is a highly selective ET_B endothelin receptor agonist (K_i values are 0.29 and 28000 nM at ET_B and ET_A receptors respectively).

Product Specifications

Molecular Weight

2516.00

Formula

C₁₀₃H₁₄₇N₂₇O₃₇S₅

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

121695-87-2

PubChem ID

71456935

InChI Key

LXPHPKVWHQLBBA-JHOSIGDNSA-N

SMILES

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Williams Characterization of cloned human endothelin receptors. Life Sci. 1993 PMID: 8336519
Miasiro Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL 1620 in the ileum. J.Cardiovasc.Pharmacol. 1998 PMID: 9595431
Williams Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 1991 PMID: 1850245
Matsuo Effects of sarafotoxin S6c on antidiuresis and NE overflow induced by stimulation of renal nerves in anesthetized dogs. J.Pharmacol.Exp.Ther. 1997 PMID: 9023305