Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

Name: Sar-[D-Phe 8 ]-des-Arg 9 -Bradykinin
Brand: Tocris Bioscience
SKU: 3230

Tocris Bioscience, part of Bio-Techne | Catalog # 3230

COA / SDS

Potent and selective B1 agonist

Discontinued Product

3230 has been discontinued. View all Bradykinin Receptor Agonists products.

Key Product Details

Description:	Potent and selective B₁ agonist
Molecular Weight:	975.11

View Full Technical Details for Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

Technical Data
Citations

Biological Activity

Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin is a potent and selective bradykinin B₁ receptor agonist (EC₅₀ = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.

Technical Data

M. Wt	975.11
Formula	C₄₇H₆₆N₁₂O₁₁
Single Letter Sequence	XRPPGFSPF (Modifications: X = Sar, Phe-9 = D-Phe)
Storage	Desiccate at -20°C
CAS Number	126959-88-4
PubChem ID	164234
InChi Key	YIUBSFCQATYQJB-VCMDLEIESA-N
Smiles	[H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References

References are publications that support the biological activity of the product.

Drapeau Development and in vivo evaluation of metabolically resistant antagonists of B₁ receptors for kinins. J.Pharmacol.Exp.Ther. 1993 PMID: 8392550
Leeb-Lundberg International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 2005 PMID: 15734727
Drapeau Hypotensive effects of Lys-des-Arg⁹-Bradykinin and metabolically protected agonists of B¹ receptors for kinins. J.Pharmacol.Exp.Ther. 1991 PMID: 1662280

Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

Tocris Bioscience, part of Bio-Techne | Catalog # 3230

Key Product Details

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

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Sar-[D-Phe8]-des-Arg9-Bradykinin

Tocris Bioscience, part of Bio-Techne | Catalog # 3230

Key Product Details

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin