(S)-(+)-Niguldipine hydrochloride

Name: ( S )-(+)-Niguldipine hydrochloride
Brand: Tocris Bioscience
SKU: 1123

Tocris Bioscience a Bio-Techne Brand

Catalog # 1123

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Key Product Details

Description:	α₁ antagonist, L-type Ca²⁺ channel blocker
Chemical Name:	(S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride
Molecular Weight:	646.18

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Biological Activity for (S)-(+)-Niguldipine hydrochloride

(S)-(+)-Niguldipine hydrochloride is a L-type Ca²⁺ channel blocker and α_1A-adrenoceptor antagonist; more active enantiomer.

R-enantiomer also available.

Technical Data for (S)-(+)-Niguldipine hydrochloride

M. Wt	646.18
Formula	C₃₆H₃₉N₃O₆.HCl
Storage	Desiccate at -20°C
CAS Number	113145-69-0
PubChem ID	6419995
InChi Key	JTQJFSQQHGPLOX-UHFFFAOYSA-N
Smiles	O=C(OC)C1=C(C)NC(C)=C(C(OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3)=O)[C@H]1[C@]2=CC=CC([N+]([O-])=O)=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-(+)-Niguldipine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	64.62	100
	ethanol	64.62	100

Preparing Stock Solutions for (S)-(+)-Niguldipine hydrochloride

The following data is based on the product molecular weight 646.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.55 mL	7.74 mL	15.48 mL
5 mM	0.31 mL	1.55 mL	3.10 mL
10 mM	0.15 mL	0.77 mL	1.55 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

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References for (S)-(+)-Niguldipine hydrochloride

References are publications that support the biological activity of the product.

Wetzel Discovery of alpha_1a-adrenergic receptor antagonists based on the L-type Ca²⁺ channel antagonist niguldipine. J.Med.Chem. 1995 PMID: 7752182
Hollt Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 1992 PMID: 1352973
Boer (+)-Niguldipine binds with very high affinity to Ca²⁺ channels and to a subtype of alpha₁-adrenoceptor. Eur.J.Pharmacol. 1989 PMID: 2548881
Graziadei Stereoselective binding of niguldipine enantiomers to alpha_1A-adrenoceptors labeled with [³H]5-methyl-urapidil. Eur.J.Pharmacol. 1989 PMID: 2555206

Citations for (S)-(+)-Niguldipine hydrochloride

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