(S)-(+)-Ketamine hydrochloride

Name: ( S )-(+)-Ketamine hydrochloride
Brand: Tocris Bioscience
SKU: 4379

Tocris Bioscience, part of Bio-Techne | Catalog # 4379

Citations (4)

COA / SDS

NMDA receptor antagonist; enantiomer of ketamine hydrochloride (Cat. No. 3131); neuroprotective

Key Product Details

Description:	NMDA receptor antagonist; enantiomer of ketamine hydrochloride (Cat. No. 3131); neuroprotective
Chemical Name:	(S)-(+)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	274.19

View Full Technical Details for (S)-(+)-Ketamine hydrochloride

Technical Data
Citations

Biological Activity for (S)-(+)-Ketamine hydrochloride

(S)-(+)-Ketamine hydrochloride is a NMDA receptor antagonist. Displays neuroprotective efficacy in vitro.

Racemate also available.

Technical Data for (S)-(+)-Ketamine hydrochloride

M. Wt	274.19
Formula	C₁₃H₁₆ClNO.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	33643-47-9
PubChem ID	44632368
InChi Key	VCMGMSHEPQENPE-ZOWNYOTGSA-N
Smiles	O=C1[C@](C2=CC=CC=C2Cl)(NC)CCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-(+)-Ketamine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	27.42	100
	DMSO	27.42	100

Preparing Stock Solutions for (S)-(+)-Ketamine hydrochloride

The following data is based on the product molecular weight 274.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.65 mL	18.24 mL	36.47 mL
5 mM	0.73 mL	3.65 mL	7.29 mL
10 mM	0.36 mL	1.82 mL	3.65 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

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References for (S)-(+)-Ketamine hydrochloride

References are publications that support the biological activity of the product.

Proescholdt Neuroprotection of S(+) KA isomer in global forebrain ischemia. Brain Res. 2001 PMID: 11406122
Benrath Low dose of S(+)-KA prevents long-term potentiation in pain pathways under strong opioid analgesia in the rat spinal cord in vivo. Br.J.Anaesth. 2005 PMID: 16113037
Ryder Comparative pharmacology of the optical isomers of KA in mice. Eur.J.Pharmacol. 1978 PMID: 658124