Rupintrivir

Name: Rupintrivir
Brand: Tocris Bioscience
SKU: 6414

Tocris Bioscience, part of Bio-Techne | Catalog # 6414

COA / SDS

Potent and selective irreversible human rhinovirus 3Cpro inhibitor

Discontinued Product

6414 has been discontinued. View all 3C and 3CL Protease Inhibitors products.

Key Product Details

Description:	Potent and selective irreversible human rhinovirus 3Cpro inhibitor
Chemical Name:	Ethyl (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate
Purity:	≥98% (HPLC)
Molecular Weight:	598.66

View Full Technical Details for Rupintrivir

Technical Data
Citations

Biological Activity for Rupintrivir

Rupintrivir is a potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC₅₀ = 5 nM). Exhibits no significant inhibition against a variety of serine and cysteine proteases. Inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Rupintrivir

M. Wt	598.66
Formula	C₃₁H₃₉FN₄O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	223537-30-2
PubChem ID	6440352CAY
InChi Key	CAYJBRBGZBCZKO-BHGBQCOSSA-N
Smiles	O=C(C1=NOC(C)=C1)N[C@@H](C(C)C)C(C[C@@H](CC2=CC=C(F)C=C2)C(N[C@H](/C=C/C(OCC)=O)C[C@@H]3CCNC3=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Rupintrivir

References are publications that support the biological activity of the product.

Dragovich Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J.Med.Chem. 1999 PMID: 10197964
Patick In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob.Agents Chemother. 1999 PMID: 10508022