RU-SKI 43 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4886

Hedgehog acyltransferase (Hhat) inhibitor; cell permeable
Discontinued Product
4886 has been discontinued. View all Hedgehog Signaling Inhibitors products.

Key Product Details

Description

Hedgehog acyltransferase (Hhat) inhibitor; cell permeable

View all Hedgehog Signaling Inhibitors »

Product Description

RU-SKI 43 hydrochloride is a hedgehog acyltransferase (Hhat) inhibitor (IC50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.

Product Specifications

Molecular Weight

423.01

Formula

C22H30N2O2S.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-((2-Methylbutyl)amino)-1-(4-((3-methylphenoxy)methyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone hydrochloride

PubChem ID

90488982

InChI Key

JBBKLHJLHRGJSQ-UHFFFAOYSA-N

SMILES

O=C(CNCC(CC)C)N1CCC3=C(C=CS3)C1COC2=CC(C)=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.3 100

Preparing Stock Solutions for RU-SKI 43 hydrochloride

The following data is based on the product molecular weight 423.01

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.82 mL 23.64 mL
5 mM 0.47 mL 2.36 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for RU-SKI 43 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RU-SKI 43 hydrochloride

For research use only

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