RS 16566 dihydrochloride

Name: RS 16566 dihydrochloride
Brand: Tocris Bioscience
SKU: 1015

Bio-Techne includes Tocris Bioscience | Catalog # 1015

Citations (1)

COA / SDS

5-HT3 ligand; shows affinity for zacopride binding site

Discontinued Product

1015 has been discontinued. View all Additional 5-HT3 Receptor Compounds products.

Key Product Details

Description:	5-HT₃ ligand; shows affinity for zacopride binding site
Chemical Name:	(R)-N-1-Azabicyclo[2.2.2]oct-3-yl-6-chloro-1-(1-methylethyl)-1H-benzimidazole-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	419.78

View Full Technical Details for RS 16566 dihydrochloride

Technical Data
Citations

Biological Activity for RS 16566 dihydrochloride

RS 16566 dihydrochloride is a high affinity ligand for the (R)-zacopride binding site (pK_i 9.84 ).

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 16566 dihydrochloride

M. Wt	419.78
Formula	C₁₈H₂₃ClN₄O.2HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1217788-97-0
PubChem ID	90479748
InChi Key	LPEOWDMQSXDYRJ-CKUXDGONSA-N
Smiles	ClC1=CC(C(N[C@@H]3C4CCN(CC4)C3)=O)=C2C(N(C(C)C)C=N2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RS 16566 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	4.2	10

Preparing Stock Solutions for RS 16566 dihydrochloride

The following data is based on the product molecular weight 419.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.82 mL	119.11 mL	238.22 mL
0.5 mM	4.76 mL	23.82 mL	47.64 mL
1 mM	2.38 mL	11.91 mL	23.82 mL
5 mM	0.48 mL	2.38 mL	4.76 mL

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References for RS 16566 dihydrochloride

References are publications that support the biological activity of the product.

Flippin (R)-3-(6-Chloro-1-isopropylbenzimidazole-4-carboxamido)quinuclidine: a high affinity ligand for the (R)-zacopride binding site. Bioorg.Med.Chem.Lett.