RS 16566 dihydrochloride

Name: RS 16566 dihydrochloride
Brand: tocris
SKU: 1015

Catalog # 1015

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	5-HT₃ ligand; shows affinity for zacopride binding site
Chemical Name:	(R)-N-1-Azabicyclo[2.2.2]oct-3-yl-6-chloro-1-(1-methylethyl)-1H-benzimidazole-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	419.78

View Full Technical Details for RS 16566 dihydrochloride

Biological Activity

High affinity ligand for the (R)-zacopride binding site (pK_i 9.84 ).

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt	419.78
Formula	C₁₈H₂₃ClN₄O.2HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1217788-97-0
PubChem ID	90479748
InChi Key	LPEOWDMQSXDYRJ-CKUXDGONSA-N
Smiles	ClC1=CC(C(N[C@@H]3C4CCN(CC4)C3)=O)=C2C(N(C(C)C)C=N2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	4.2	10

Preparing Stock Solutions

The following data is based on the product molecular weight 419.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.82 mL	119.11 mL	238.22 mL
0.5 mM	4.76 mL	23.82 mL	47.64 mL
1 mM	2.38 mL	11.91 mL	23.82 mL
5 mM	0.48 mL	2.38 mL	4.76 mL

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References

References are publications that support the biological activity of the product.

Flippin (R)-3-(6-Chloro-1-isopropylbenzimidazole-4-carboxamido)quinuclidine: a high affinity ligand for the (R)-zacopride binding site. Bioorg.Med.Chem.Lett.

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for RS 16566 dihydrochloride include:

Otvos et al. (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. J Neurosci. 7:2336
PMID: 26114334

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Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

RS 16566 dihydrochloride

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Key Product Details

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Biological Activity

Licensing Information

Technical Data

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Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

SDS

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