Rp-8-pCPT-cGMPS sodium

Name: Rp-8-pCPT-cGMPS sodium
Brand: Tocris Bioscience
SKU: 5524

Tocris Bioscience, part of Bio-Techne | Catalog # 5524

Citations (1)

COA / SDS

PKG inhibitor

Discontinued Product

5524 has been discontinued. View all Protein Kinase G Inhibitors products.

Key Product Details

Description:	PKG inhibitor
Chemical Name:	8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium
Purity:	≥99% (HPLC)
Molecular Weight:	525.86

View Full Technical Details for Rp-8-pCPT-cGMPS sodium

Technical Data
Citations

Biological Activity for Rp-8-pCPT-cGMPS sodium

Rp-8-pCPT-cGMPS sodium is a PKG inhibitor (K_i values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.

Technical Data for Rp-8-pCPT-cGMPS sodium

M. Wt	525.86
Formula	C₁₆H₁₄ClN₅NaO₆PS₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	208445-07-2
PubChem ID	91826097
InChi Key	JERAACMSJYSCBY-OZOPYAHTSA-M
Smiles	O=C1N=C(N)NC2=C1N=C(SC4=CC=C(Cl)C=C4)N2[C@@H]3O[C@@](CO[P@](O5)(S[Na])=O)([H])[C@]5([H])[C@H]3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Rp-8-pCPT-cGMPS sodium

References are publications that support the biological activity of the product.

Poppe Cyclic nucleotide analogs as probes of signaling pathways. Nat.Methods 2008 PMID: 18376388
Gamm The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J.Biol.Chem. 1995 PMID: 7593002
Kim Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca²⁺-permeable AMPA receptors. Proc.Natl.Acad.Sci.U.S.A. 2015 PMID: 25713349

Rp-8-pCPT-cGMPS sodium

Tocris Bioscience, part of Bio-Techne | Catalog # 5524

Key Product Details

Biological Activity for Rp-8-pCPT-cGMPS sodium

Technical Data for Rp-8-pCPT-cGMPS sodium

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Rp-8-pCPT-cGMPS sodium

Product Documents for Rp-8-pCPT-cGMPS sodium

COA

Certificate of Analysis

SDS

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