RO 8191

Name: RO 8191
Brand: Tocris Bioscience
SKU: 7375

Tocris Bioscience, part of Bio-Techne | Catalog # 7375

Citations (1)

COA / SDS

IFNα receptor 2 agonist

Discontinued Product

7375 has been discontinued. View all IFN-alpha/beta R2 products.

Key Product Details

Description:	IFNα receptor 2 agonist
Chemical Name:	8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine
Purity:	≥98% (HPLC)
Molecular Weight:	373.22

View Full Technical Details for RO 8191

Technical Data
Citations

Biological Activity for RO 8191

RO 8191 is an IFNα receptor 2 (IFNAR2) agonist (EC₅₀= 0.2 μM). RO 8191 induces phosphorylation and activation of STAT1 and STAT2. RO 8191 inhibits hepatitis C (HCV) cell culture-produced infectious particles and HCV subgenomic replicon (IC₅₀ values 0.20 μM and 0.17 μM, respectively) and inhibits hepatitis B virus replication in cell cultures (IC₅₀ = 0.1 μM). In an animal model RO 8191 inhibits prion invasion and prolongs survival; it also reverses the inhibitory effect of integrin β6 (ITGB6) on the JAK/STAT3 signaling and the epithelial-to-mesenchymal transition pathway and inhibits the proliferation, invasion, and migration of cervical cancer cells. Orally bioavailable.

Technical Data for RO 8191

M. Wt	373.22
Formula	C₁₄H₅F₆N₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	691868-88-9
PubChem ID	2768133
InChi Key	GRHYZVJEXKTJOS-UHFFFAOYSA-N
Smiles	FC(F)(C1=CC(C(F)(F)F)=C2C=CC3=NC(C4=NN=CO4)=CN3C2=N1)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for RO 8191

References are publications that support the biological activity of the product.

Ishibashi Type I interferon protects neurons from prions in in vivo models. Brain 2019 PMID: 30753318
Zheng Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway. Ann.Transl.Med. 2021 PMID: 34268416
Furutani An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes. PLoS One 2019 PMID: 31188831
Konishi An orally available, small-molecule interferon inhibits viral replication. Sci.Rep. 2012 PMID: 22355771

RO 8191

Tocris Bioscience, part of Bio-Techne | Catalog # 7375

Key Product Details

Biological Activity for RO 8191

Technical Data for RO 8191

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for RO 8191

Product Documents for RO 8191

COA

Certificate of Analysis

SDS

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