Ro 51

Tocris Bioscience, part of Bio-Techne | Catalog # 4391

Potent P2X3 and P2X2/3 antagonist
Discontinued Product
4391 has been discontinued. View all P2X Receptor Antagonists products.

Key Product Details

Description

Potent P2X3 and P2X2/3 antagonist

View all P2X Receptor Antagonists »

Product Description

Ro 51 is a potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Selective for P2X3 and P2X2/3 over other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). Cell permeable.

Product Specifications

Molecular Weight

474.29

Formula

C17H23IN4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol

CAS Number

1050670-85-3

PubChem ID

24883277

InChI Key

PAYROHWFGZADBR-UHFFFAOYSA-N

SMILES

NC1=NC(NC(CO)CO)=NC=C1OC2=C(C(C)C)C=C(OC)C(I)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.43 100
Ethanol 47.43 100

Preparing Stock Solutions for Ro 51

The following data is based on the product molecular weight 474.29

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Ro 51

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ro 51

For research use only

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