Ro 19-4603

Tocris Bioscience, part of Bio-Techne | Catalog # 1995

Benzodiazepine inverse agonist
Discontinued Product
1995 has been discontinued. View all Benzodiazepine Inverse Agonists products.

Key Product Details

Description

Benzodiazepine inverse agonist

View all Benzodiazepine Inverse Agonists »

Product Description

Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.

Product Specifications

Molecular Weight

319.38

Formula

C15H17N3O3S

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester

CAS Number

99632-94-7

PubChem ID

127382

InChI Key

ZIGMMUKDYCABPW-UHFFFAOYSA-N

SMILES

CN1CC2=C(N=CN2C2=C(SC=C2)C1=O)C(=O)OC(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.94 100
Ethanol 31.94 100

Preparing Stock Solutions for Ro 19-4603

The following data is based on the product molecular weight 319.38

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.31 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Ro 19-4603

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ro 19-4603

For research use only

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