Ro 04-6790

Name: Ro 04-6790
Brand: Tocris Bioscience
SKU: 2911

Tocris Bioscience, part of Bio-Techne | Catalog # 2911

COA / SDS

Potent and selective 5-HT6 antagonist

Discontinued Product

2911 has been discontinued. View all 5-HT6 Receptor Antagonists products.

Key Product Details

Description:	Potent and selective 5-HT₆ antagonist
Chemical Name:	4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	308.36

View Full Technical Details for Ro 04-6790

Technical Data
Citations

Biological Activity for Ro 04-6790

Ro 04-6790 is a potent and selective 5-HT₆ receptor antagonist (pK_i values are 7.26 and 7.35 at rat and human 5-HT₆ receptors respectively). Displays no affinity at a range of other receptors (IC₅₀ > 10 μM). Induces stretching behavior in rats in vivo.

Technical Data for Ro 04-6790

M. Wt	308.36
Formula	C₁₂H₁₆N₆O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	202466-68-0
PubChem ID	5312145
InChi Key	JELFWSXQTXRMAJ-UHFFFAOYSA-N
Smiles	NC1=CC=C(S(NC2=NC(NC)=NC(NC)=C2)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ro 04-6790

References are publications that support the biological activity of the product.

Bentley Investigation of stretching behaviour induced by the selective 5-HT₆ receptor antagonist, Ro 04-6790, in rats. Br.J.Pharmacol. 1999 PMID: 10323584
Fone An update on the role of the 5-hydroxytryptamine₆ receptor in cognitive function. Neuropharmacology 2008 PMID: 18655798
Sleight Characterization of Ro 04-6790 and Ro 63-2563: potent and selective antagonists at human and rat 5-HT₆ receptors. Br.J.Pharmacol. 1998 PMID: 9647481

Ro 04-6790

Tocris Bioscience, part of Bio-Techne | Catalog # 2911

Key Product Details

Biological Activity for Ro 04-6790

Technical Data for Ro 04-6790

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Ro 04-6790

Product Documents for Ro 04-6790

COA

Certificate of Analysis

SDS

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