Rizatriptan benzoate

Name: Rizatriptan benzoate
Brand: Tocris Bioscience
SKU: 5136

Tocris Bioscience a Bio-Techne Brand

Catalog # 5136

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Key Product Details

Description:	Potent 5-HT_1B and 5-HT_1D agonist
Alternative Names:	MK 462
Chemical Name:	N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine benzoate
Purity:	≥99% (HPLC)
Molecular Weight:	391.47

View Full Technical Details for Rizatriptan benzoate

Biological Activity for Rizatriptan benzoate

Rizatriptan benzoate is a 5-HT_1B/1D agonist. Antimigraine agent; attenuates effects of CGRP on light aversion in mice. Orally bioavailable.

Compound Libraries for Rizatriptan benzoate

Rizatriptan benzoate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rizatriptan benzoate

M. Wt	391.47
Formula	C₁₅H₁₉N₅.C₇H₆O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	145202-66-0
PubChem ID	77997
InChi Key	JPRXYLQNJJVCMZ-UHFFFAOYSA-N
Smiles	CN(CCC2=CNC1=CC=C(CN3N=CN=C3)C=C12)C.O=C(C4=CC=CC=C4)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rizatriptan benzoate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	39.15	100
	DMSO	19.57	50

Preparing Stock Solutions for Rizatriptan benzoate

The following data is based on the product molecular weight 391.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.77 mL	25.54 mL
5 mM	0.51 mL	2.55 mL	5.11 mL
10 mM	0.26 mL	1.28 mL	2.55 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for Rizatriptan benzoate

References are publications that support the biological activity of the product.

Kaiser Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT1B/D agonist. J.Neurosci. 2012 PMID: 23115181
Street Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. J.Med.Chem. 1995 PMID: 7752204

Citations for Rizatriptan benzoate

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Rizatriptan benzoate

Tocris Bioscience a Bio-Techne Brand

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