Rizatriptan benzoate
Tocris Bioscience, part of Bio-Techne | Catalog # 5136
Potent 5-HT1B and 5-HT1D agonist
Discontinued Product
5136 has been discontinued.
View all 5-HT1B Receptor Agonists products.
Key Product Details
Description
Potent 5-HT1B and 5-HT1D agonist
Alternative Names
MK 462
Product Description
Rizatriptan benzoate is a 5-HT1B/1D agonist. Antimigraine agent; attenuates effects of CGRP on light aversion in mice. Orally bioavailable.Product Specifications
Molecular Weight
391.47
Formula
C15H19N5.C7H6O2
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine benzoate
CAS Number
145202-66-0
PubChem ID
77997
InChI Key
JPRXYLQNJJVCMZ-UHFFFAOYSA-N
SMILES
CN(CCC2=CNC1=CC=C(CN3N=CN=C3)C=C12)C.O=C(C4=CC=CC=C4)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 39.15 | 100 | |
| DMSO | 19.57 | 50 |
Preparing Stock Solutions
for Rizatriptan benzoate
The following data is based on the product molecular weight 391.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.77 mL | 25.54 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Street Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. J.Med.Chem. 1995 PMID: 7752204
- Kaiser Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT1B/D agonist. J.Neurosci. 2012 PMID: 23115181
Product Specific Notices for Rizatriptan benzoate
For research use only
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