Rifaximin

Name: Rifaximin
Brand: Tocris Bioscience
SKU: 5359
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5359

(1)

COA / SDS

Pregnane X receptor agonist; antibiotic

Discontinued Product

5359 has been discontinued. View all Pregnane X Receptor Agonists products.

Key Product Details

Description:	Pregnane X receptor agonist; antibiotic
Chemical Name:	(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	785.88

View Full Technical Details for Rifaximin

Technical Data
Citations / Reviews (1)

Biological Activity for Rifaximin

Rifaximin is a pregnane X receptor (PXR) agonist; antibiotic. Reduces number of colon tumors and suppresses expression of TNFα and Il-1β induced in a colon cancer, PXR-humanized mouse model. Increases apoptosis and decreased proliferation in HT-29 cells. Exhibits low gastrointestinal absorption while retaining its antibacterial activity. Active against gram-positive and gram-negative bacteria.

Compound Libraries for Rifaximin

Rifaximin is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rifaximin

M. Wt	785.88
Formula	C₄₃H₅₁N₃O₁₁
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	80621-81-4
PubChem ID	6436173
InChi Key	NZCRJKRKKOLAOJ-XRCRFVBUSA-N
Smiles	O=C(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]5(C)O4)O)C)NC2=C(O)C1=C(O)C(C)=C4C(C5=O)=C1C3=C2N6C(C=C(C)C=C6)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Rifaximin

References are publications that support the biological activity of the product.

Jiang Rifaximin: in vitro and in vivo antibacterial activity-a review. Chemotherapy 2005 PMID: 15855749
Stradi Structural elucidation of the rifa. Ph. Eur. Impurity H. J.Pharm.Biomed.Anal. 2010 PMID: 19926422
Cheng Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J.Pharmacol.Exp.Ther. 2014 PMID: 25277138