RFRP 3 (human) is an agonist of the NPFF₁ receptor (IC₅₀ = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.

Product Specifications

Molecular Weight

969.15

Formula

C₄₅H₇₂N₁₄O₁₀

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

311309-27-0

PubChem ID

71451611

InChI Key

JFZCLMZUABKABL-GVCDGELBSA-N

SMILES

[H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Ubuka Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One 2009 PMID: 20027225
Hinuma New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell Biol. 2000 PMID: 11025660
Rizwan RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 2012 PMID: 22691552

RFRP 3 (human)

Tocris Bioscience, part of Bio-Techne | Catalog # 4683

Key Product Details

Description

Alternative Names

View all Neuropeptide FF/AF Receptor Agonists »

Product Description