Remoxipride hydrochloride

Name: Remoxipride hydrochloride
Brand: tocris
SKU: 0916

Catalog # 0916

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	Selective D₂-like antagonist
Chemical Name:	(S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamide hydrochloride
Molecular Weight:	407.73

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Biological Activity

Dopamine D₂ receptor antagonist showing selectivity over D₃ and D₄ receptors (K_i values are ~ 300, ~ 1600, and ~ 2800 nM for D₂, D₃ and D₄ receptors respectively). Exhibits antipsychotic activity in vivo with no extrapyramidal side effects. 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.

Technical Data

M. Wt	407.73
Formula	C₁₆H₂₃BrN₂O₃.HCl
Storage	Store at RT
CAS Number	73220-03-8
PubChem ID	15565709
InChi Key	WCPXLMIPGMFZMY-MERQFXBCSA-N
Smiles	BrC1=CC=C(OC)C(C(NC[C@@]2(CCCN2CC)[H])=O)=C1OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 407.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.26 mL	24.53 mL
5 mM	0.49 mL	2.45 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.45 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References

References are publications that support the biological activity of the product.

Ahlenius In vivo effects of remoxipride and aromatic ring metabolites in the rat. J.Pharmacol.Exp.Ther. 1997 PMID: 9400011
Mohell Binding characteristics of remoxipride and its metabolites to DA D₂ and D₃ receptors. Eur.J.Pharmacol. 1993 PMID: 8405075
Sedvall Development of a new antipsychotic remoxipride. Acta Psychiatr.Scand.Suppl. 1990 PMID: 1978466
Seeman and Van Tol DA receptor pharmacology. TiPS 1994 PMID: 7940991

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Remoxipride hydrochloride include:

André et al. (2011) Differential electrophysiological changes in striatal output neurons in Huntington's disease. J Neurosci. 31:1170
PMID: 21273402

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Product Datasheets

COA

Certificate of Analysis

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Remoxipride hydrochloride

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Key Product Details

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Biological Activity

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Solubility

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Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

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