Remacemide hydrochloride

Name: Remacemide hydrochloride
Brand: Tocris Bioscience
SKU: 1622

Tocris Bioscience, part of Bio-Techne | Catalog # 1622

COA / SDS

NMDA antagonist; blocks ion channel and allosteric modulatory site

Discontinued Product

1622 has been discontinued. View all NMDA Receptor Antagonists products.

Key Product Details

Description:	NMDA antagonist; blocks ion channel and allosteric modulatory site
Alternative Names:	FPL 12924AA
Chemical Name:	2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	304.82

View Full Technical Details for Remacemide hydrochloride

Technical Data
Citations

Biological Activity for Remacemide hydrochloride

Remacemide hydrochloride is an non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC₅₀ = 8 - 68 mM). Remacemide hydrochloride is anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na⁺ channels (IC₅₀ = 161 mM). In an animal model of Huntington's disease, extends survival and delays disease; this effect is more pronounced when combined with Coenzyme Q10 (Cat. No. 3003)

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for Remacemide hydrochloride

M. Wt	304.82
Formula	C₁₇H₂₀N₂O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	111686-79-4
PubChem ID	60510
InChi Key	HYQMIUSWZXGTCC-UHFFFAOYSA-N
Smiles	Cl.CC(CC1=CC=CC=C1)(NC(=O)CN)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Remacemide hydrochloride

References are publications that support the biological activity of the product.

Ferrante Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J.Neurosci. 2002 PMID: 11880489
Santangeli Na⁺ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur.J.Pharmacol. 2002 PMID: 11906711
Subramaniam Block of the N-MthD.-aspartate receptor by remacemide and its des-glycine metabolite. J.Pharmacol.Exp.Ther. 1996 PMID: 8558426
Palmer Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann.N.Y.Acad.Sci. 1995 PMID: 7486610