RBC8
Tocris Bioscience, part of Bio-Techne | Catalog # 5411
RalA and RalB inhibitor
Discontinued Product
5411 has been discontinued.
View all Ras GTPase Inhibitors products.
Product Description
RBC8 is a RalA and RalB GTPase inhibitor (EC50 ~3.5 μM). Inhibits the binding of Ral to RaLBP1. Exhibits no detectable inhibition of Ras or RhoA activity. Suppresses growth of xenograft tumors in mice. Cell permeable.Product Specifications
Molecular Weight
424.45
Formula
C25H20N4O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile
CAS Number
361185-42-4
PubChem ID
6626226
InChI Key
CLMQBVUFKIKYLU-UHFFFAOYSA-N
SMILES
NC1=C(C#N)C(C5=C(OC)C=CC(OC)=C5)C(C(C3=CC=C(C=CC=C4)C4=C3)=NN2)=C2O1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.44 | 100 |
Preparing Stock Solutions
for RBC8
The following data is based on the product molecular weight 424.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.36 mL | 11.78 mL | 23.56 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.71 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.36 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yan Discovery and characterization of small molecules that target the GTPase Ral. Nature 2014 PMID: 25219851
Product Specific Notices for RBC8
For research use only
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