Ranolazine dihydrochloride

Name: Ranolazine dihydrochloride
Brand: Tocris Bioscience
SKU: 3118
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3118

(2)

Citations (6)

COA / SDS

Antianginal, activates pyruvate dehydrogenase

Key Product Details

Description:	Antianginal, activates pyruvate dehydrogenase
Alternative Names:	RS 43285
Chemical Name:	N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	500.46

View Full Technical Details for Ranolazine dihydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for Ranolazine dihydrochloride

Ranolazine dihydrochloride is an antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I_Na and I_Kr currents.

Compound Libraries for Ranolazine dihydrochloride

Ranolazine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ranolazine dihydrochloride

M. Wt	500.46
Formula	C₂₄H₃₃N₃O₄.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	95635-56-6
PubChem ID	71279
InChi Key	RJNSNFZXAZXOFX-UHFFFAOYSA-N
Smiles	COC1=CC=CC=C1OCC(CN2CCN(CC(NC3=C(C)C=CC=C3C)=O)CC2)O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ranolazine dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	50.05	100
	DMSO	50.05	100

Preparing Stock Solutions for Ranolazine dihydrochloride

The following data is based on the product molecular weight 500.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.99 mL	19.98 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for Ranolazine dihydrochloride

References are publications that support the biological activity of the product.

Shryock and Belardinelli Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. Br.J.Pharmacol. 2008 PMID: 18071302
Wang Antitorsadogenic effects of (+/-)-N-(2,6-dimethyl-phenyl)-4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J.Pharmacol.Exp.Ther. 2008 PMID: 18322148
Zacharowski Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur.J.Pharmacol. 2001 PMID: 11334871