Ranolazine dihydrochloride

Name: Ranolazine dihydrochloride
Brand: Tocris Bioscience
SKU: 3118
Rating: 5 (2 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 3118

Citations (3)

(2)

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Key Product Details

Description:	Antianginal, activates pyruvate dehydrogenase
Alternative Names:	RS 43285
Chemical Name:	N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	500.46

View Full Technical Details for Ranolazine dihydrochloride

Biological Activity for Ranolazine dihydrochloride

Ranolazine dihydrochloride is an antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I_Na and I_Kr currents.

Compound Libraries for Ranolazine dihydrochloride

Ranolazine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ranolazine dihydrochloride

M. Wt	500.46
Formula	C₂₄H₃₃N₃O₄.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	95635-56-6
PubChem ID	71279
InChi Key	RJNSNFZXAZXOFX-UHFFFAOYSA-N
Smiles	COC1=CC=CC=C1OCC(CN2CCN(CC(NC3=C(C)C=CC=C3C)=O)CC2)O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ranolazine dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	50.05	100
	DMSO	50.05	100

Preparing Stock Solutions for Ranolazine dihydrochloride

The following data is based on the product molecular weight 500.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.99 mL	19.98 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for Ranolazine dihydrochloride

References are publications that support the biological activity of the product.

Shryock and Belardinelli Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. Br.J.Pharmacol. 2008 PMID: 18071302
Wang Antitorsadogenic effects of (+/-)-N-(2,6-dimethyl-phenyl)-4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J.Pharmacol.Exp.Ther. 2008 PMID: 18322148
Zacharowski Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur.J.Pharmacol. 2001 PMID: 11334871

Citations for Ranolazine dihydrochloride (3)

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Citations are publications that use Bio-Techne products. Selected citations for Ranolazine dihydrochloride include:

Carstensen et al. (2019) Effects of UK 68798 and RS 43285 on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation. J Cardiovasc Electrophysiol. 30:596
PMID: 30661267
McKeithan et al. (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 8:766
PMID: 29075196
Park et al. (2013) Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons. J Neurophysiol. 109:1378
PMID: 23236005

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Customer Reviews for Ranolazine dihydrochloride (2)

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Reversal of HOCl-LDL induced arrhythmia by ranolazine superfusion

Name: Chintan Koyani

Species: Other

Assay Type: In Vitro

Cell Line/Tissue: Cardiomyocytes

Guinea pig ventricular cardiomyocytes were treated (12-16 h) with HOCl-LDL (250 µg/ml). Cells were patched and stimulated at a frequency of 1 Hz. Representative action potentials (shown in Image) recorded in the same cell are shown before (A) and after (B) superfusion with Ranolazine (10 µM, 5 min). For comparative purpose representative APs of a control cardiomyocyte are shown (C).
Ranolazine to block fatty acid oxidation

Name: Anonymous

Species: Mouse

Assay Type: Ex Vivo

Cell Line/Tissue: Brain slice

Application of Ranolazine on acute brain slices to verify for fatty acid oxidation involvement in studied process. It had the same effect as etomoxir (CPT1 blocker), as expected per hypothesis.

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Product Documents for Ranolazine dihydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.