Ramipril

Name: Ramipril
Brand: Tocris Bioscience
SKU: 5250

Tocris Bioscience, part of Bio-Techne | Catalog # 5250

COA / SDS

Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor

Discontinued Product

5250 has been discontinued. View all ACE Inhibitors products.

Key Product Details

Description:	Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor
Chemical Name:	(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Purity:	≥99% (HPLC)
Molecular Weight:	416.51

View Full Technical Details for Ramipril

Technical Data
Citations

Biological Activity for Ramipril

Ramipril is a non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC₅₀ = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.

Compound Libraries for Ramipril

Ramipril is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ramipril

M. Wt	416.51
Formula	C₂₃H₃₂N₂O₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	87333-19-5
PubChem ID	5362129
InChi Key	HDACQVRGBOVJII-JBDAPHQKSA-N
Smiles	[H][C@@]12CCC[C@@]([H])1N(C([C@H](C)N[C@H]([C@@](OCC)=O)CCC3=CC=CC=C3)=O)[C@H]([C@@](O)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ramipril

References are publications that support the biological activity of the product.

Levitt Human physiologically based pharmacokinetic model for ACE inhibitors: ram. and ramiprilat. BMC Clin. Pharmacol. 2006 PMID: 16398929
Stevens Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp.Biochem.Physiol C. 1988 PMID: 2905962
Tian Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKK beta /AMPK and heme oxygenase-1 activation. J.Pharmacol.Exp.Ther. 2014 PMID: 24741076