(R)-Norketamine hydrochloride

Name: ( R )-Norketamine hydrochloride
Brand: Tocris Bioscience
SKU: 5996

Tocris Bioscience, part of Bio-Techne | Catalog # 5996

Citations (4)

COA / SDS

NMDA receptor modulator; analgesic

Key Product Details

Description:	NMDA receptor modulator; analgesic
Chemical Name:	(R)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	260.16

View Full Technical Details for (R)-Norketamine hydrochloride

Technical Data
Citations

Biological Activity for (R)-Norketamine hydrochloride

(R)-Norketamine hydrochloride is a NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC₅₀ = 91 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.

S-enantiomer and racemate also available.

Technical Data for (R)-Norketamine hydrochloride

M. Wt	260.16
Formula	C₁₂H₁₄ClNO.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	83777-68-8
PubChem ID	71743680
InChi Key	CLPOJGPBUGCUKT-UTONKHPSSA-N
Smiles	ClC1=C([C@@]2(N)C(CCCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-Norketamine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	5.2	20
	DMSO	26.02	100

Preparing Stock Solutions for (R)-Norketamine hydrochloride

The following data is based on the product molecular weight 260.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.84 mL	19.22 mL	38.44 mL
5 mM	0.77 mL	3.84 mL	7.69 mL
10 mM	0.38 mL	1.92 mL	3.84 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

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References for (R)-Norketamine hydrochloride

References are publications that support the biological activity of the product.

Holtman Effects of norKA enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 2008 PMID: 18586315
Singh KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 2016 PMID: 27096720