Norketamine hydrochloride

Name: Norketamine hydrochloride
Brand: Tocris Bioscience
SKU: 1970

Tocris Bioscience, part of Bio-Techne | Catalog # 1970

Citations (14)

COA / SDS

Potent non-competitive NMDA antagonist; antinociceptive

Key Product Details

Description:	Potent non-competitive NMDA antagonist; antinociceptive
Chemical Name:	2-Amino-2-(2-chlorophenyl)cyclohexanone hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	260.16

View Full Technical Details for Norketamine hydrochloride

Technical Data
Citations

Biological Activity for Norketamine hydrochloride

Norketamine hydrochloride is a major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (K_i = 3.6 μM for displacement of [³H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo.

R-enantiomer and S-enantiomer also available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Norketamine hydrochloride

M. Wt	260.16
Formula	C₁₂H₁₄ClNO.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	79499-59-5
PubChem ID	25195026
InChi Key	CLPOJGPBUGCUKT-UHFFFAOYSA-N
Smiles	Cl.NC1(CCCCC1=O)C1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Norketamine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	26.02	100

Preparing Stock Solutions for Norketamine hydrochloride

The following data is based on the product molecular weight 260.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.84 mL	19.22 mL	38.44 mL
5 mM	0.77 mL	3.84 mL	7.69 mL
10 mM	0.38 mL	1.92 mL	3.84 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

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References for Norketamine hydrochloride

References are publications that support the biological activity of the product.

Ebert NorKA, the main metabolite of KA, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur.J.Pharmacol. 1997 PMID: 9311667
Shimoyama Oral KA is antinociceptive in the rat formalin test: role of the metabolite, norKA. Pain 1999 PMID: 10353496
Leung Comparative pharmacology in the rat of KA and its two principal metabolites, norKA and (Z)-6-hydroxynorKA. J.Med.Chem. 1986 PMID: 3783598