(R)-(+)-HA-966

Name: ( R )-(+)-HA-966
Brand: Tocris Bioscience
SKU: 0281

Catalog # 0281

Citations (1)

COA / SDS

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Key Product Details

Description:	NMDA partial agonist/antagonist; acts at glycine site
Chemical Name:	(R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	116.12

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Biological Activity

(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier.

S-enantiomer also available.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt	116.12
Formula	C₄H₈N₂O₂
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	123931-04-4
PubChem ID	6603720
InChi Key	HCKUBNLZMKAEIN-GSVOUGTGSA-N
Smiles	N[C@@H]1CCN(O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	11.61	100

Preparing Stock Solutions

The following data is based on the product molecular weight 116.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	8.61 mL	43.06 mL	86.12 mL
5 mM	1.72 mL	8.61 mL	17.22 mL
10 mM	0.86 mL	4.31 mL	8.61 mL
50 mM	0.17 mL	0.86 mL	1.72 mL

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References

References are publications that support the biological activity of the product.

Kemp and Priestley Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-MthD.-aspartate receptor agonist responses in cat cultured cortical neurons. Mol.Pharmacol. 1991 PMID: 1674587
Pullan Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966). Eur.J.Pharmacol. 1991 PMID: 1834473
Pullan Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-MthD.-aspartate receptor complex. J.Neurochem. 1990 PMID: 1975835

Citations for (<em>R</em>)-(+)-HA-966 (1)

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Citations are publications that use Bio-Techne products. Selected citations for (R)-(+)-HA-966 include:

Paquette et al. (2008) σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias. Elife. 19:111
PMID: 18281903

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