Pyroxamide

Name: Pyroxamide
Brand: Tocris Bioscience
SKU: 4403
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4403

(1)

Citations (11)

COA / SDS

Histone deacetylase inhibitor

Discontinued Product

4403 has been discontinued. View all Class I Histone Deacetylases Inhibitors products.

Key Product Details

Description:	Histone deacetylase inhibitor
Chemical Name:	N-Hydroxy-N'-3-pyridinyloctanediamide
Purity:	≥98% (HPLC)
Molecular Weight:	265.31

View Full Technical Details for Pyroxamide

Technical Data
Citations / Reviews (1)

Biological Activity for Pyroxamide

Pyroxamide is an inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.

Technical Data for Pyroxamide

M. Wt	265.31
Formula	C₁₃H₁₉N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	382180-17-8
PubChem ID	4996
InChi Key	PTJGLFIIZFVFJV-UHFFFAOYSA-N
Smiles	O=C(CCCCCCC(NO)=O)NC1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Pyroxamide

References are publications that support the biological activity of the product.

Carrillo Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). Bioorg.Med.Chem. 2015 PMID: 25637120
Remiszewski Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J.Med.Chem. 2002 PMID: 11831887
Bradner Chemical phylogenetics of histone deacetylases. Nat.Chem.Biol. 2010 PMID: 20139990
Butler Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin.Cancer Res. 2001 PMID: 11309347

Pyroxamide

Tocris Bioscience, part of Bio-Techne | Catalog # 4403

Key Product Details

Biological Activity for Pyroxamide

Technical Data for Pyroxamide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Pyroxamide

Product Documents for Pyroxamide

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected