PS 1145 dihydrochloride

Name: PS 1145 dihydrochloride
Brand: Tocris Bioscience
SKU: 4569

Tocris Bioscience, part of Bio-Techne | Catalog # 4569

Citations (5)

COA / SDS

Selective IKK inhibitor; orally active

Discontinued Product

4569 has been discontinued. View all IkB Kinase Inhibitors products.

Key Product Details

Description:	Selective IKK inhibitor; orally active
Chemical Name:	N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	395.67

View Full Technical Details for PS 1145 dihydrochloride

Technical Data
Citations

Biological Activity for PS 1145 dihydrochloride

PS 1145 dihydrochloride is a selective IκB kinase (IKK) inhibitor (IC₅₀ = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.

Technical Data for PS 1145 dihydrochloride

M. Wt	395.67
Formula	C₁₇H₁₁ClN₄O.2HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1049743-58-9
PubChem ID	16219884
InChi Key	QTDCBADLGJZBHP-UHFFFAOYSA-N
Smiles	ClC1=CC(NC(C4=CC=CN=C4)=O)=C(NC3=C2C=CN=C3)C2=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PS 1145 dihydrochloride

References are publications that support the biological activity of the product.

Newton Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J.Pharmacol.Exp.Ther. 2007 PMID: 17322026
Hideshima NF-kappa B as a therapeutic target in multiple myeloma. J.Biol.Chem. 2002 PMID: 11872748
Castro Novel IKK inhibitors: beta-carbolines. Bioorg.Med.Chem.Lett. 2003 PMID: 12824047

PS 1145 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4569

Key Product Details

Biological Activity for PS 1145 dihydrochloride

Technical Data for PS 1145 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PS 1145 dihydrochloride

Product Documents for PS 1145 dihydrochloride

COA

Certificate of Analysis

SDS

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