PS 1145 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4569
Selective IKK inhibitor; orally active
Discontinued Product
4569 has been discontinued.
View all IkB Kinase Inhibitors products.
Key Product Details
Description
Selective IKK inhibitor; orally active
Product Description
PS 1145 dihydrochloride is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.Product Specifications
Molecular Weight
395.67
Formula
C17H11ClN4O.2HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
CAS Number
1049743-58-9
PubChem ID
16219884
InChI Key
QTDCBADLGJZBHP-UHFFFAOYSA-N
SMILES
ClC1=CC(NC(C4=CC=CN=C4)=O)=C(NC3=C2C=CN=C3)C2=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1.98 | 5 with gentle warming |
Preparing Stock Solutions
for PS 1145 dihydrochloride
The following data is based on the product molecular weight 395.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 50.55 mL | 252.74 mL | 505.47 mL |
| 0.25 mM | 10.11 mL | 50.55 mL | 101.09 mL |
| 0.5 mM | 5.05 mL | 25.27 mL | 50.55 mL |
| 2.5 mM | 1.01 mL | 5.05 mL | 10.11 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Newton Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J.Pharmacol.Exp.Ther. 2007 PMID: 17322026
- Hideshima NF-kappa B as a therapeutic target in multiple myeloma. J.Biol.Chem. 2002 PMID: 11872748
- Castro Novel IKK inhibitors: beta-carbolines. Bioorg.Med.Chem.Lett. 2003 PMID: 12824047
Product Specific Notices for PS 1145 dihydrochloride
For research use only
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