PRIMA-1

Tocris Bioscience, part of Bio-Techne | Catalog # 1862

Restores mutant p53 activity; induces apoptosis
Discontinued Product
1862 has been discontinued. View all Additional p53-related Compounds products.

Key Product Details

Description

Restores mutant p53 activity; induces apoptosis

View all Additional p53-related Compounds »

Product Description

PRIMA-1 is a selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.

Product Specifications

Molecular Weight

185.22

Formula

C9H15NO3

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one

CAS Number

5608-24-2

PubChem ID

322968

InChI Key

RFBVBRVVOPAAFS-UHFFFAOYSA-N

SMILES

O=C1C(CO)(CO)N2CCC1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.52 100

Preparing Stock Solutions for PRIMA-1

The following data is based on the product molecular weight 185.22

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.40 mL 26.99 mL 53.99 mL
5 mM 1.08 mL 5.40 mL 10.80 mL
10 mM 0.54 mL 2.70 mL 5.40 mL
50 mM 0.11 mL 0.54 mL 1.08 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for PRIMA-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PRIMA-1

For research use only

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