PP 121

Name: PP 121
Brand: Tocris Bioscience
SKU: 3894

Tocris Bioscience a Bio-Techne Brand

Catalog # 3894

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Key Product Details

Description:	Dual kinase inhibitor; inhibits PI 3-K family kinases
Chemical Name:	1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	319.36

View Full Technical Details for PP 121

Biological Activity for PP 121

PP 121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC₅₀ μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC₅₀ μM for p110α, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.

Compound Libraries for PP 121

PP 121 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PP 121

M. Wt	319.36
Formula	C₁₇H₁₇N₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1092788-83-4
PubChem ID	24905142
InChi Key	NVRXTLZYXZNATH-UHFFFAOYSA-N
Smiles	NC1=C2C(N(C5CCCC5)N=C2C3=CN=C(NC=C4)C4=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PP 121

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.94	100
	ethanol	15.97	50

Preparing Stock Solutions for PP 121

The following data is based on the product molecular weight 319.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.66 mL	31.31 mL
5 mM	0.63 mL	3.13 mL	6.26 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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References for PP 121

References are publications that support the biological activity of the product.

Apsel Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol. 2008 PMID: 18849971

Citations for PP 121

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