PP 121

Name: PP 121
Brand: Tocris Bioscience
SKU: 3894

Tocris Bioscience, part of Bio-Techne | Catalog # 3894

Citations (6)

COA / SDS

Dual kinase inhibitor; inhibits PI 3-K family kinases

Discontinued Product

3894 has been discontinued. View all PI 3-Kinase Inhibitors products.

Key Product Details

Description:	Dual kinase inhibitor; inhibits PI 3-K family kinases
Chemical Name:	1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	319.36

View Full Technical Details for PP 121

Technical Data
Citations

Biological Activity for PP 121

PP 121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC₅₀ < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC₅₀ < 0.06 μM for p110α, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.

Compound Libraries for PP 121

PP 121 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PP 121

M. Wt	319.36
Formula	C₁₇H₁₇N₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1092788-83-4
PubChem ID	24905142
InChi Key	NVRXTLZYXZNATH-UHFFFAOYSA-N
Smiles	NC1=C2C(N(C5CCCC5)N=C2C3=CN=C(NC=C4)C4=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PP 121

References are publications that support the biological activity of the product.

Apsel Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol. 2008 PMID: 18849971